Crisp is expected to stay away from baseball activity until Friday, following an off-day.
"I think [Monday's] game got him a little bit nauseous," manager Bob Melvin said. "Last night, I think he had some struggles as the game went along. We'll take it day by day. I think we're that much closer, but maybe last night was a little quick."
Crisp has been sidelined by a head cold that led to an inner ear problem. After missing the final two games in Anaheim and all of the Indians series over the weekend, Crisp returned to the lineup on Monday and went 1-for-3 with a walk.
Melvin said Crisp was visibly ill but did not want to be taken out of the game.
"I think he found that with the activity it got him a little dizzy," Melvin said.
With Crisp out again, Melvin played Jonny Gomes in left field, while starting Seth Smith at designated hitter. Elsewhere in the lineup, Eric Sogard and Anthony Recker garnered starts at shortstop and catcher, respectively, while Cliff Pennington and Kurt Suzuki got the day off.