Hughes had been scheduled to start on Friday but pulled out of the lineup just prior to batting practice because he did not feel well enough to play. Manager Bob Melvin replaced Hughes with Eric Sogard, who responded by hitting a two-run homer in the second inning that gave the A's a two-run lead en route to a 5-2 victory.
Hughes went back to the hotel on Friday night and got a good night sleep, and he felt much better prior to Saturday's game.
The A's claimed Hughes off waivers from the Twins last Sunday. He started at third base on Monday and Tuesday, going 0-for-6 before falling ill.
"It knocked me down for a few days, but I'm feeling better," Hughes said. "I'm still getting over it, but I'm definitely feeling better today. I had a fever of about 102 or something. I had a good sleep last night and kind of broke a sweat, which I think was a good thing."
Melvin said that he should have been a bit more cautious with Hughes prior to Friday's game, but he was confident the third baseman was ready for the second game of the three-game series.
"Hopefully, this is the end of it," Hughes said. "Tomorrow, hopefully, I'll feel even better."