A's manager Bob Melvin confirmed after Tuesday's 8-5 victory over the Rockies that Cespedes will start Wednesday's contest.
The A's outfielder, sidelined since last Thursday with a strained left hamstring, was deemed available off the bench as a pinch-hitting option on Tuesday for the first of a three-game series with the Rockies.
The A's are 19-16 with Cespedes in the lineup and 8-19 when he doesn't play.
He ran a lot better [on Tuesday]," Melvin said before Tuesday's game. "He's definitely an option off the bench and could see a start here very soon."