It was the first time Crisp had been ejected this season.
After drawing a full count, Crisp was called out on strikes on a ball that appeared to be thrown to the outside part of the plate by San Francisco's Madison Bumgarner. Thinking he had been walked, the 32-year-old initially made a move to first base.
He immediately began voicing his displeasure with the call to Randazzo and appeared to continue to argue as he walked toward the dugout. Crisp wasn't ejected until after the inning, leading A's manager Bob Melvin to come out to argue with Randazzo as well. Melvin, though, was not thrown out.
Right fielder Josh Reddick slid over to center to replace Crisp, and Seth Smith came off the bench to take Reddick's spot in right.