"He's probably doubtful for [Saturday]," manager Bob Melvin said.
It's unclear how Cespedes sustained the injury, though he made an awkward slide while attempting to steal third base in the sixth. He was replaced in the lineup by the newly promoted Michael Taylor when his turn in the order came two frames later.
Cespedes was 2-for-4 with a pair of infield singles on the night before departing the contest.
Jane Lee is a reporter for MLB.com. Read her blog, Major Lee-ague, and follow her on Twitter @JaneMLB. Ben Estes is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.