Wednesday's performance, said A's manager Bob Melvin, fully endured him to his latest set of teammates.
"To break out and have a night like he had, he makes himself comfortable with the team," Melvin said. "It was a big pickup for us."
Lowrie doubled twice, hit a home run and drove in three runs for the A's in their 6-2 victory over the Mariners.
Lowrie started the season at shortstop when Hiroyuki Nakajima went on the disabled list.
Rick Eymer is a contributor to MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.