"They both hit in the cage today," said manager Bob Melvin, "and said they felt good to go."
Cobb has had trouble getting both hitters out in his career, with Crisp entering the day 8-for-15 with two homers off him and Lowrie 4-for-7.
Elsewhere in the lineup, Josh Donaldson got the start at designated hitter, while Alberto Callaspo started at third base, as part of manager Bob Melvin's effort to keep each of his regulars off the artificial turf at least a day during this swing through St. Petersburg and Toronto.
Jane Lee is a reporter for MLB.com. Read her blog, Major Lee-ague, and follow her on Twitter @JaneMLB. This story was not subject to the approval of Major League Baseball or its clubs.