Melvin improved to 9-for-16 on challenge attempts, but the Astros went ahead on L.J. Hoes' solo homer off Fernando Abad in the 12th.
"They were aggressive on the bases," Melvin said. "We did all right in that fashion, we just came up one run short and a couple big hits short."
Aaron Leibowitz is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.