The A's reliever, rehabbing from right shoulder tendinitis that had him begin the season on the disabled list, walked two and struck out one in the first frame of the River Cats' mid-morning contest.
Wuertz entered the outing having allowed just two hits and a walk, next to one strikeout, in two innings of rehab work.
Following a 2009 season in which he made a team-leading 74 appearances while posting a 2.63 ERA, Wuertz appeared in just two Spring Training games due to the sore shoulder.
The 31-year-old Wuertz is in the midst of his first career stint on the DL. In the meantime, Oakland's bullpen entered Wednesday having posted a 3.35 ERA -- good for fifth lowest in the American League.